gene_symbol
CD276
hgnc_id
HGNC:19137
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Engineered T cells bearing a chimeric NK receptor recognize tumor-associated ligands (not B7-H3) on B7-H3–positive tumor cells, signal via ITAM/CD3ζ, and kill via perforin/granzyme-mediated cytolysis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Enrollment requires tumor B7-H3 positivity by IHC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06751134
disease_id_num_tar_ref
1367
drug_id_num_tar_ref
3706