gene_symbol
IL3RA
hgnc_id
HGNC:6012
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR T cells recognize CD123 on target cells, form an immunologic synapse, and induce apoptosis via perforin/granzyme release (and possibly Fas/FasL).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor subunit expressed on AML blasts and leukemic stem cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05995041
disease_id_num_tar_ref
1423
drug_id_num_tar_ref
3847