gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
LM-302 targets CLDN18.2 on the cell surface; after internalization it releases MMAE, which binds beta-tubulin to disrupt microtubules and induce G2/M arrest and apoptosis. Beta-tubulin expression alone does not lead to targeting or direct killing by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MMAE payload binds the vinca site to inhibit microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06351020
disease_id_num_tar_ref
1459
drug_id_num_tar_ref
3943