gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Daxdilimab binds ILT7 on pDCs; its afucosylated Fc engages FcγRIIIa (CD16A) on NK cells to trigger ADCC that kills ILT7+ pDCs. CD16A-expressing cells act as effectors and are not killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Afucosylated IgG1 Fc enhances affinity and ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05540665
disease_id_num_tar_ref
1460
drug_id_num_tar_ref
3946