gene_symbol
TIGIT
hgnc_id
HGNC:26838
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-TIGIT IgG1 binds TIGIT on cells and engages Fcγ receptors on NK cells/macrophages to mediate ADCC/ADCP (and potentially CDC), depleting TIGIT-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Inhibitory immune checkpoint receptor on T and NK cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05791097
disease_id_num_tar_ref
1481
drug_id_num_tar_ref
4000