gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Ociperlimab binds TIGIT on target cells and its IgG1 Fc engages CD16A on NK cells to trigger ADCC/ADCP against TIGIT+ cells; CD16A-expressing cells act as effectors, not targets.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
IgG1 Fc engagement mediating ADCC on NK cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05791097
disease_id_num_tar_ref
1481
drug_id_num_tar_ref
4000