gene_symbol
FCGR2A
hgnc_id
HGNC:3616
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Ociperlimab binds TIGIT; its IgG1 Fc engages Fcγ receptors (including CD32A) on myeloid/NK cells to mediate ADCC/ADCP of TIGIT-expressing cells. CD32A+ cells act as effectors and are not targeted or killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
IgG1 Fc engagement supporting ADCP on myeloid cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05791097
disease_id_num_tar_ref
1481
drug_id_num_tar_ref
4000