gene_symbol
FCGR1A
hgnc_id
HGNC:3613
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The antibody binds TIGIT on target cells and uses its IgG1 Fc to engage CD64 on effector myeloid cells, driving ADCC/ADCP against TIGIT+ cells. CD64+ cells serve as effectors and are not directly killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
High-affinity IgG1 Fc engagement; phagocytic effector functions
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05791097
disease_id_num_tar_ref
1481
drug_id_num_tar_ref
4000