gene_symbol
FCGR2B
hgnc_id
HGNC:3618
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Ociperlimab targets TIGIT, not FcγRIIB (CD32B). Its IgG1 Fc can mediate ADCC/ADCP against TIGIT-expressing cells, but CD32B+ cells are not bound/opsonized by the antibody and are not directly killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Inhibitory Fcγ receptor that can be engaged by IgG1 Fc
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05791097
disease_id_num_tar_ref
1481
drug_id_num_tar_ref
4000