gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Disitamab vedotin targets HER2, is internalized, and releases MMAE, which binds the β‑tubulin vinca site to block microtubule polymerization, causing mitotic arrest and apoptosis; ADCC/bystander effects may contribute.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Microtubule polymerization inhibitor via MMAE payload
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05745740
disease_id_num_tar_ref
1493
drug_id_num_tar_ref
4031