gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The vaccine primes/expands neoantigen-specific CD8+ T cells, which recognize the mutant peptide–HLA I complexes on tumor cells and kill them via perforin/granzyme and Fas–FasL–mediated apoptosis.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
HLA class I–restricted epitopes recognized by CD8+ T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05949775
disease_id_num_tar_ref
1499
drug_id_num_tar_ref
4050