gene_symbol
FOLR1
hgnc_id
HGNC:3791
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The DC vaccine primes FRα-specific CD8+ T cells (with Th1 help). These CTLs recognize FRα-derived peptides on MHC I of tumor cells and kill them via perforin/granzyme (±Fas–FasL); induced anti-FRα IgG may also mediate ADCC.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Multi-epitope FRα peptides presented on MHC class I and II to elicit CD8+ and CD4+ T-cell responses; may also induce anti-FRα IgG
trial_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05920798
disease_id_num_tar_ref
1525
drug_id_num_tar_ref
4115