gene_symbol
MSLN
hgnc_id
HGNC:7371
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-mesothelin CAR-engineered macrophages bind mesothelin on target cells and directly kill them via CAR-triggered phagocytosis and macrophage cytotoxic effector functions; inflammatory cytokines may augment this.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Membrane-bound, GPI-anchored mesothelin on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06562647
disease_id_num_tar_ref
1530
drug_id_num_tar_ref
4129