gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
GD2-specific CAR T cells bind GD2 on target cells, triggering T-cell activation and immune synapse formation, leading to perforin/granzyme-mediated cytolysis (and Fas–FasL apoptosis).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface glycolipid (ganglioside) highly expressed on neuroblastoma
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05990751
disease_id_num_tar_ref
1541
drug_id_num_tar_ref
4164