gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds HER2 on tumor cells, is internalized, and releases a topoisomerase‑1 inhibitor that stabilizes topo‑1–DNA cleavage complexes, causing DNA strand breaks, cell‑cycle arrest, and apoptosis.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Bispecific antibody binds two non-overlapping epitopes in the extracellular dimerization domain of HER2 on tumor cells.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06226766
disease_id_num_tar_ref
1573
drug_id_num_tar_ref
4263