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gene_symbol
CD47
hgnc_id
HGNC:1682
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Blocks CD47–SIRPα “don’t‑eat‑me” signaling, enabling macrophage Fc-receptor–mediated phagocytosis (ADCP) of CD47+ cells and subsequent immune-mediated killing; may also enhance downstream T‑cell responses via antigen presentation.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks CD47–SIRPA interaction
trial_id_tar_ref
drug_id_tar_ref
nct_id_tar_ref
NCT06601335
disease_id_num_tar_ref
1588
drug_id_num_tar_ref
4301