gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-TROP2 ADC binds TROP2, is internalized, and releases a topoisomerase I inhibitor payload that induces DNA damage and tumor cell death (with potential bystander effect).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface antigen (ADC binding and internalization)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06393374
disease_id_num_tar_ref
1594
drug_id_num_tar_ref
4320