gene_symbol
CD8A
hgnc_id
HGNC:1706
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ATG antibodies bind CD8α on T cells and induce complement-dependent lysis and Fc-mediated effector killing (ADCC and phagocytosis), depleting CD8+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell coreceptor
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05508009
disease_id_num_tar_ref
1653
drug_id_num_tar_ref
4475