gene_symbol
CEACAM5
hgnc_id
HGNC:1817
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC antibody binds CEACAM5 on tumor cells, is internalized, and releases MMAE, which inhibits tubulin polymerization causing G2/M arrest and apoptotic cell death.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
N-glycosylated epitope on CEACAM5
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05701527
disease_id_num_tar_ref
1673
drug_id_num_tar_ref
4520