gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds HER2 and is internalized; a cleavable linker releases MMAE, inhibiting tubulin and causing G2/M arrest and apoptosis. Fc engagement can also mediate ADCC; a bystander effect may occur.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface receptor tyrosine kinase
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06227325
disease_id_num_tar_ref
1723
drug_id_num_tar_ref
4650