gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The vaccine primes HBV-specific CD8+ T cells via dendritic-cell antigen presentation; activated CTLs then recognize HBV peptide–MHC I complexes on infected hepatocytes and kill them via perforin/granzyme (and Fas–FasL). MHC I expression itself is not the cytotoxic target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Represents polymorphic HLA-A/B/C molecules on dendritic cells that bind ISA104 peptides for CD8+ T-cell presentation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05841095
disease_id_num_tar_ref
1726
drug_id_num_tar_ref
4664