gene_symbol
HLA-DRA
hgnc_id
HGNC:4947
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Peptide vaccine is taken up by dendritic cells and presented on MHC I/II to prime HBV‑specific CD8+ T cells and Th1 cells; the activated CTLs then kill HBV‑infected hepatocytes via perforin/granzyme-mediated cytotoxicity. MHC II–expressing APCs are not directly killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Represents HLA-DR/DP/DQ molecules on dendritic cells that bind ISA104 peptides for CD4+ T-cell presentation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05841095
disease_id_num_tar_ref
1726
drug_id_num_tar_ref
4664