gene_symbol
TNFRSF4
hgnc_id
HGNC:11918
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Afucosylated IgG1 binding to OX40 recruits FcγRIIIa-expressing effectors (e.g., NK cells) to mediate ADCC, with possible ADCP, depleting OX40+ T cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Co-stimulatory TNF receptor on activated effector/memory T cells; binding blocks OX40–OX40L signaling and enables ADCC-mediated depletion of OX40+ cells.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05704738
disease_id_num_tar_ref
1738
drug_id_num_tar_ref
4687