gene_symbol
MDM2
hgnc_id
HGNC:6973
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The DNA vaccine primes MDM2-specific CD8+ T cells; these CTLs recognize MDM2-derived peptides on MHC I of tumor cells and kill them via perforin/granzyme-mediated cytolysis (with Th1 CD4+ help).
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Th1-biased MHC I/II-presented peptides
trial_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05242965
disease_id_num_tar_ref
1777
drug_id_num_tar_ref
4778