gene_symbol
FCGRT
hgnc_id
HGNC:3621
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
VRC01.23LS binds HIV-1 gp120, not FcRn. LS mutations enhance FcRn-mediated recycling to extend half-life; they do not direct cytotoxicity toward FcRn-expressing cells. Any killing is of HIV Env–expressing infected cells via Fc-mediated ADCC/ADCP, not of FcRn+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Enhanced Fc–FcRn affinity via LS (M428L/N434S) Fc mutations; pH-dependent binding
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05959707
disease_id_num_tar_ref
195
drug_id_num_tar_ref
528