gene_symbol
FKBP1A
hgnc_id
HGNC:3711
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Rimiducid binds the engineered FKBP12(F36V) domains in the iCasp9 switch, dimerizing and activating caspase-9 and triggering downstream caspase-3/7–mediated apoptosis of the modified cells.
enzyme_product
Off
epitope
Off
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
AP1903 (rimiducid) induces homodimerization of FKBP12-F36V domains fused to caspase-9
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04715191
disease_id_num_tar_ref
1779
drug_id_num_tar_ref
4788