gene_symbol
CD276
hgnc_id
HGNC:19137
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds B7-H3 on tumor cells, is internalized, and releases a cytotoxic payload inside the cell, leading to target-cell death (e.g., via DNA damage or microtubule disruption).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface immune-regulatory ligand overexpressed on solid tumors
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06426680
disease_id_num_tar_ref
1821
drug_id_num_tar_ref
4872