gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR T cells bind CD19 via the CAR, become activated, and kill CD19+ cells through perforin/granzyme-mediated cytolysis and apoptosis (and death-receptor pathways), independent of MHC.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MHC-independent CAR scFv binding to CD19 on B cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05852717
disease_id_num_tar_ref
1825
drug_id_num_tar_ref
4882