gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Binding CD3 activates and redirects T cells; the engaged T cells kill EGFR-positive tumor cells via perforin/granzyme cytotoxicity, not the CD3+ T cells themselves.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Antibody arm binds the CD3ε chain on T cells to trigger cytotoxic activation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06479239
disease_id_num_tar_ref
1877
drug_id_num_tar_ref
4993