gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The bispecific links CD3 on T cells to EGFR on target cells, activating T cells to kill EGFR+ cells via immune-synapse–mediated perforin/granzyme cytotoxicity (and Fas/FasL).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain of EGFR on tumor cells to mediate T-cell redirection
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06479239
disease_id_num_tar_ref
1877
drug_id_num_tar_ref
4993