gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti‑CD19 CAR T cells bind CD19 on target B cells, triggering T‑cell activation and immune synapse formation with perforin/granzyme release (and Fas/FasL signaling), causing lysis/apoptosis of CD19+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface B-cell antigen; not HLA-restricted
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05934838
disease_id_num_tar_ref
1878
drug_id_num_tar_ref
4995