gene_symbol
CLDN18
hgnc_id
HGNC:2039
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Antibody binds CLDN18.2 on tumor cells and engages Fc effector functions to trigger ADCC (via NK cells/macrophages) and complement-dependent cytotoxicity (CDC), leading to lysis of CLDN18.2+ cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
Extracellular domain of tight-junction protein on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06177041
disease_id_num_tar_ref
1905
drug_id_num_tar_ref
5070