gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds HER2 on target cells, is internalized, and releases MMAE, which disrupts microtubules to cause mitotic arrest and apoptosis; Fc effector function can also trigger ADCC.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds HER2 including HER2-low; enables ADC internalization and MMAE delivery
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06105008
disease_id_num_tar_ref
1954
drug_id_num_tar_ref
5233