gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds HER2 (not beta-tubulin), is internalized, and releases MMAE that binds the vinca site on beta-tubulin to disrupt microtubules and trigger apoptosis; Fc-mediated ADCC may also contribute.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MMAE payload inhibits microtubule polymerization at the vinca domain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06105008
disease_id_num_tar_ref
1954
drug_id_num_tar_ref
5233