gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-HER2 IgG1 binds HER2 and its Fc engages Fcγ receptor–bearing effector cells (e.g., NK cells) to trigger antibody-dependent cellular cytotoxicity (ADCC), with possible complement activation; signaling blockade itself is non-cytolytic.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds HER2 extracellular domain subdomain II (dimerization arm), blocking ligand-dependent HER2 dimerization (especially HER2/HER3)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05720026
disease_id_num_tar_ref
1973
drug_id_num_tar_ref
5276