gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
After binding HER2, trastuzumab’s Fc engages Fcγ receptors on NK cells and other effectors to mediate ADCC (and some CDC), resulting in killing of HER2-expressing cells.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (domain IV) of HER2 to block signaling and mediate ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05020860
disease_id_num_tar_ref
1987
drug_id_num_tar_ref
5310