gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The IgG1 antibody binds the Env gp120 V2 apex on infected cells and engages Fcγ receptors to trigger NK-cell ADCC and macrophage ADCP (and potentially complement/CDC), killing Env-expressing cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Quaternary V2 apex epitope; requires N160 glycan; trimer apex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06508749
disease_id_num_tar_ref
2055
drug_id_num_tar_ref
5496