gene_symbol
FCGRT
hgnc_id
HGNC:3621
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
PGDM1400LS targets HIV-1 Env, enabling FcγR-mediated ADCC/ADCP against Env-expressing infected cells. Its LS mutation increases FcRn binding for IgG recycling; FcRn-expressing cells are not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
LS Fc mutations (M428L/N434S) increase FcRn affinity at acidic pH and extend half-life
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06508749
disease_id_num_tar_ref
2055
drug_id_num_tar_ref
5496