gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-HER2 ADC binds HER2, is internalized, and releases MMAE via a cleavable linker; MMAE disrupts microtubules causing G2/M arrest and apoptosis (with possible bystander killing).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC antibody component binds HER2 extracellular domain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06112041
disease_id_num_tar_ref
2058
drug_id_num_tar_ref
5505