gene_symbol
CD276
hgnc_id
HGNC:19137
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 antibody binds B7-H3 on tumor cells and engages FcγR-expressing effector cells (e.g., NK cells, macrophages) to induce ADCC and antibody-dependent cellular phagocytosis, killing target-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface immune checkpoint ligand widely expressed on tumors and tumor vasculature
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05338580
disease_id_num_tar_ref
2123
drug_id_num_tar_ref
5682