gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CD19-specific CAR-T cells bind CD19 on target cells, become activated (CD3zeta with costimulation) and kill via perforin/granzyme-mediated cytotoxicity leading to apoptosis/lysis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface B-cell antigen on malignant and normal B cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06450067
disease_id_num_tar_ref
2138
drug_id_num_tar_ref
5713