gene_symbol
WT1
hgnc_id
HGNC:12796
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Dendritic-cell vaccination primes WT1-specific CD8+ T cells, which recognize WT1 peptides on MHC I of tumor cells and kill them via perforin/granzyme-mediated apoptosis (with CD4+ T-cell help).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Presented by autologous CD141+ dendritic cells on HLA class I and class II to prime CD8+ and CD4+ T cells
trial_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06172634
disease_id_num_tar_ref
2255
drug_id_num_tar_ref
6030