gene_symbol
LY75
hgnc_id
HGNC:6729
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds CD205 on target cells, is internalized, and releases the maytansinoid DM4 after linker cleavage; DM4 binds tubulin, disrupts microtubules, induces mitotic arrest, and kills the CD205-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC binding and internalization on CD205-expressing cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05930951
disease_id_num_tar_ref
2273
drug_id_num_tar_ref
6081