gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds CD205 on target cells, is internalized, and releases DM4; DM4 then binds β‑tubulin to disrupt microtubules and induce mitotic cell death. β‑tubulin itself is not the targeted antigen; killing occurs only after CD205-mediated delivery.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
DM4 payload binds β-tubulin and disrupts microtubules
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05930951
disease_id_num_tar_ref
2273
drug_id_num_tar_ref
6081