gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Trastuzumab binds HER2 on target cells, is internalized, and releases the DM1 microtubule inhibitor, causing mitotic arrest and cell death; its Fc also engages immune effectors to mediate ADCC against HER2+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Trastuzumab component; binds HER2 extracellular domain (domain IV)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06481956
disease_id_num_tar_ref
2278
drug_id_num_tar_ref
6099