gene_symbol
ITGB6
hgnc_id
HGNC:6161
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds ITGB6 on tumor cells, is internalized, and releases MMAE that inhibits tubulin polymerization, causing mitotic arrest and cell death.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface subunit of the αvβ6 integrin; antibody component mediates internalization for MMAE delivery
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06549816
disease_id_num_tar_ref
2385
drug_id_num_tar_ref
6357