gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
AFNT-211 TCR-T cells recognize the KRAS G12V peptide presented by HLA-A*11:01 and kill the presenting cell via TCR-mediated cytotoxicity (perforin/granzyme). HLA-A*11:01 heavy chain alone is not a cytotoxic target; killing requires the KRAS G12V peptide–HLA complex.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Bound by co-expressed CD8α/β co-receptor (alpha3 domain) to strengthen TCR signaling
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06105021
disease_id_num_tar_ref
2408
drug_id_num_tar_ref
6431