gene_symbol
FASLG
hgnc_id
HGNC:11936
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
FasL is not a killing target; the Fas-4-1BB switch receptor converts FasL engagement into 4-1BB costimulation, enhancing T-cell activation and persistence. Killing occurs only when the TCR recognizes KRAS G12V peptide-HLA-A*11:01, leading to perforin/granzyme-mediated lysis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Engages Fas ectodomain of Fas–4-1BB switch receptor to deliver CD137 (4-1BB) costimulation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06105021
disease_id_num_tar_ref
2408
drug_id_num_tar_ref
6431