gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The vaccine primes neoantigen-specific T cells via APC presentation; tumor killing occurs when CD8+ CTLs recognize neoantigen peptides on MHC I and induce perforin/granzyme-mediated apoptosis. Cells presenting MHC II–restricted neoantigen peptides (typically APCs) are not directly killed by the drug.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
CD4+ T-cell epitopes presented on HLA-DR/DP/DQ; derived from somatic mutations
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06497010
disease_id_num_tar_ref
2603
drug_id_num_tar_ref
6951