gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds HER2 (not β‑tubulin), is internalized, and releases MMAE, which binds β‑tubulin to inhibit microtubule polymerization, causing G2/M arrest and apoptosis (with possible bystander killing).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Target of MMAE payload at vinca-binding site to inhibit microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06574763
disease_id_num_tar_ref
2656
drug_id_num_tar_ref
7082